{
  "driver": "Twist1",
  "full_nodes": 17191,
  "full_directed_edges": 1891745,
  "responses_total": 182,
  "responses_in_network": 168,
  "responses_missing_unconnected": [
    "Gpr110",
    "Lphn3",
    "Odz3",
    "E030013I19Rik",
    "Slco1a5",
    "Gbp8",
    "Fut2",
    "Btbd11",
    "Sept8",
    "3110079O15Rik",
    "2610528A11Rik",
    "2010111I01Rik",
    "1600029D21Rik",
    "St5"
  ],
  "subnetwork_nodes": 1200,
  "subnetwork_edges": 228199,
  "conservation_max_rel_dev": 1.9857079656097954e-15,
  "nt": 16,
  "r": 0.5,
  "dt": 0.0002176969788190783,
  "assay_genes_with_readout": 19,
  "assay_overlap_subnetwork": 18,
  "spearman_NetPertweight_vs_dissemination": 0.31246871216948197,
  "spearman_p": 0.20679753345042623,
  "top20_NetPert": [
    "Pdgfra",
    "Htt",
    "Tp53",
    "Ctnnb1",
    "Cdh1",
    "Zranb1",
    "Vim",
    "Ppia",
    "Stat3",
    "Clu",
    "Stub1",
    "Nfkb1",
    "Ep300",
    "Sox2",
    "Col2a1",
    "Rela",
    "Kif23",
    "Hif1a",
    "Hdac6",
    "H4c1"
  ],
  "data_sources": {
    "ppi": "IID mouse_annotated_PPIs.txt.gz (symbol1/symbol2), http://iid.ophid.utoronto.ca",
    "tf": "TRRUST v2 mouse (grnpedia.org), 7057 pairs",
    "responses": "netpert_v1 manuscript_netpert/responses.csv (Twist1 + 182 DE genes, Shamir et al organoids)",
    "assays": "EwaldLab 2019_Prkd1 Georgess_Prkd1_2019_Data_Final.xlsx Fig.1 (real IC50 + dissemination %)",
    "drugs": "Drug Repurposing Hub 20200324 + MGI HOM_MouseHumanSequence.rpt"
  }
}